Chromogranin A in heart failure
نویسندگان
چکیده
منابع مشابه
Chromogranin A in heart failure.
Since the initial demonstration of increased circulating norepinephrine in patients with chronic heart failure, a large number of investigations on neuroendocrine activation in heart failure have followed. It is now clear that persistent activation of neuroendocrine systems, notably the adrenergic system and the renin–angiotensin system is maladaptive in heart failure (reviewed in). In this iss...
متن کاملChromogranin B in Heart Failure: A Putative Cardiac Biomarker Expressed in the Failing Myocardium Running Title: Chromogranin B in Heart Failure
Background: Chromogranin B (CgB) is a member of the granin protein family. As CgB is often co-localized with chromogranin A (CgA), a recently discovered cardiac biomarker, we hypothesized that CgB is regulated during heart failure (HF) development. Methods and Results: CgB regulation was investigated in patients with chronic HF and in a post-myocardial infarction (MI) HF mouse model. Animals we...
متن کاملChromogranin A in heart failure; a novel neurohumoral factor and a predictor for mortality.
BACKGROUND In chronic heart failure, several hormonal systems are activated with diagnostic and prognostic implications. We tested the hypotheses that serum Chromogranin-A (CgA) -- a 49 kDa acid protein present in the secretor granules of neuroendocrine cells -- is increased in chronic heart failure and that CgA levels are a predictive factor for mortality. METHOD AND RESULTS In 160 patients ...
متن کاملChromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium.
BACKGROUND Chromogranin B (CgB) is a member of the granin protein family. Because CgB is often colocalized with chromogranin A (CgA), a recently discovered cardiac biomarker, we hypothesized that CgB is regulated during heart failure (HF) development. METHODS AND RESULTS CgB regulation was investigated in patients with chronic HF and in a post-myocardial infarction HF mouse model. Animals wer...
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During a period of four years between June, IS, 1988 to June, IS, 1992 one hundred and fourteen patients with congestive heart failure (CHF) were admitted to the pediatric department of Taleghani General Hospital. During the above period, 192 patients with heart disease were hospitalized at this department and CHF was the cause of admission in 59.4% of them. Congenital heart disease (CHO) w...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2002
ISSN: 0195-668X
DOI: 10.1053/euhj.2001.3132